Inhibition of Striatal miR-141-3p Ameliorates Cognitive Deficits and Neuroinflammation in an ADHD Animal Model

Background/Objectives: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity that may persist into adulthood. Emerging evidence suggests that microRNAs (miRNAs) contribute to ADHD pathogenesis, but the role of miR-141-3p remains unclear. This study investigated the effects of miR-141-3p inhibition on ADHD-like behaviors in spontaneous hypertensive rats (SHRs). Methods: We used RT-qPCR, immunoblotting,…

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