CONCLUSIONS: In this exploratory study, FH-BD, AUD, and ANX were associated with poor response, though only FH-AUD remained significant after adjusting for clinical factors. PRS-BD predicted better response, while PRS-MDD was associated with worse response. These findings suggest independent and potentially complementary roles of FH and PRS. Integrating both familial and genetic risk measures may improve personalized treatment strategies and outcomes for BD patients.
