Brain region and cell type-specific DNA methylation profiles in association with ADHD

Previous studies identified DNA methylation (DNAm) associations with ADHD in peripheral tissue and the brain. Given that DNAm is highly cell type-specific, it is crucial to understand which cell types are driving the DNAm differences observed in ADHD. Here, we report the first brain cell type-specific epigenome-wide association study (EWAS) for ADHD (25 individuals with ADHD, 33 individuals without ADHD) in postmortem anterior cingulate cortex (ACC) and caudate nucleus (CN) based on epigenomic…

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