Acute elevation of anandamide and 2-AG levels modulates defensive behavior in a sex- and strain-dependent manner in an animal model of attention-deficit/hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) is linked to heightened risk-taking tendencies. Core symptoms and traits, such as impulsivity, hyperactivity, and risk-taking, stem from dysfunctions in frontostriatal circuitry. The endocannabinoid system (ECS) modulates frontostriatal dynamics and monoaminergic signaling. The pair of strains, spontaneously hypertensive rats (SHRs) and Wistar Kyoto (WKY) rats, is an established model for ADHD. The endocannabinoids 2-arachidonoylglycerol (2-AG) and…

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