A double-blind randomised controlled trial protocol comparing dexamphetamine and placebo effectiveness for obesity management in primary care settings

Obesity is a growing health and economic burden. This study investigates dexamphetamine, an inexpensive drug, as a potential safe and effective treatment for obesity when combined with diet and lifestyle changes over six months in general practice. The trial is a double-blind, randomised, placebo-controlled study with a six-month active treatment phase and two years of follow-up. Participants are randomised 1:1 to receive either dexamphetamine or placebo, starting at 5 mg twice daily, with…

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