Working memory deficits and altered prefrontal-hippocampal activation in p35 knockout mice with ADHD-like phenotypes: influence of sex and acute monoaminergic treatments

Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental condition characterized by persistent deficits in working memory (WM) and executive control. Dysregulation of the Cyclin-dependent kinase 5 (Cdk5)/p35 signaling pathway has been implicated in ADHD pathophysiology due to its impact on neuronal connectivity and dopamine regulation. Using p35 knockout (p35KO) mice-an animal model exhibiting ADHD-like phenotypes-we investigated WM performance, task-related c-Fos…

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