White-matter functional connectivity uniquely predicts brain age, cognition, and psychopathology beyond gray-matter connectivity

White-matter pathways form the structural backbone for communication across the human connectome, yet whether functional connectivity (FC) involving white matter carries information beyond gray-matter networks remains unclear. Here, we tested whether white-matter FC (W-M FC) uniquely predicted brain age, cognition, and psychopathology. Across four independent developmental cohorts spanning childhood to young adulthood (total n = 2,370), we showed that W-M FC, including both white-white and…

via https://pubmed.ncbi.nlm.nih.gov/42574643/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1HYeX0emtvYgH07Wkz0a8n9otrdMd-JIklc_uo0I5vh1u9WMEy&fc=None&ff=20260811010804&v=2.20.1


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