The large-conductance, Ca²⁺- and voltage-activated K⁺ (BK) channels are widely distributed in the central nervous system, where they play diverse roles in regulating brain activity. The γ1 (LRRC26) subunit functions as a potent activator of BK channels, inducing a large shift in the voltage dependence of channel activation toward the hyperpolarized direction. Given the large conductance of BK channels, their activators have promising therapeutic potential for the treatment of various diseases….
