Mental disorders and substance use disorders (SUDs) are significant public health challenges among adolescents and young adults (AYAs). This study quantified global and regional prevalence, disability-adjusted life-years (DALYs), and years lived with disability (YLDs), and temporal trends of mental disorders and SUDs among AYAs from 1990-2021. Estimates were generated using DisMod-MR 2.1, with standardized case definitions, severity weights, and pandemic-period adjustments. Temporal trends were…
