CLINICAL CHARACTERISTICS: Temple syndrome (TS14) is characterized by pre- and postnatal growth failure with head sparing, hypotonia with poor feeding, precocious puberty, early-onset obesity with high fat mass and low lean mass, short stature (which can be exacerbated by untreated precocious puberty), and characteristic facial features. Affected individuals can experience cardiometabolic syndrome, including hypertension, hypercholesterolemia, and diabetes, at an early age as a primary feature of…
