Mast cells can release different kinds of molecules as a response to different stimuli, particularly proinflammatory mediators that contribute to neuroinflammation. The enrichment of mast cells in specific areas of the nervous system and gastrointestinal tract, together with their degranulation, histamine and neuropeptide secretion, such as substance P, and mast cell-microglia interactions, may promote neuroinflammatory signaling in neurological and psychiatric disorders during childhood and…
