Adverse drug reaction (ADR) detection in post-market surveillance is limited by underreporting and the absence of drug utilization data. This study proposes three signal detection metrics-including a TF-IDF-inspired method (EF-IDF) and two prescription-adjusted measures-to improve pharmacovigilance, using ADHD medications and the FDA Adverse Event Reporting System (FAERS) as a case study. We standardized drug and ADR entities, integrated prescription data from Bloomberg Intelligence, and…
