PTPRD pleiotropy, genetically driven childbirth timing, and corpus callosum microstructure as potential mechanisms underlying ADHD-RLS comorbidity

CONCLUSIONS: Our findings suggest that the PTPRD gene may contribute to the comorbidity of ADHD and RLS through pleiotropic effects. Genetically influenced childbirth timing and alterations in corpus callosum white matter microstructure may represent potential neurodevelopmental pathways linking the two conditions.

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