Psychiatric safety of methylphenidate in adults with major depressive disorder: a 1-year retrospective cohort study of 6,422 patients

CONCLUSIONS: In adults with MDD, methylphenidate use was associated with a lower risk of hospitalization or emergency visits and was not linked to increased risk of suicidality, mania, or recurrence. These findings support the psychiatric safety of methylphenidate as an adjunctive treatment for selected patients, though longer follow-up is needed.

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