Population-level trends of Psychiatric Medication Co-Prescriptions in Persons with Epilepsy: an EPIC Cosmos Study

Persons with epilepsy (PWE) experience high rates of psychiatric comorbidity, yet the population-scale pharmacoepidemiology of psychiatric medication (PM) use alongside antiseizure medications (ASMs) has not been previously characterized. Using Epic Cosmos, a federated electronic health record network spanning >300 million patients across >2,000 hospital systems, we examined patterns of ASM and PM co-prescriptions in PWE (ICD-10 G40.x) every year between 2018-2025. PM prescriptions were…

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