Polygenic scores for precision psychiatry: a study on the effect heterogeneity of antidepressants

CONCLUSIONS AND RELEVANCE: The genetic predisposition to psychiatric disorders may, at least partially, underlie the heterogeneity in the risk of suicidal thoughts with antidepressant use. In the personalized medicine framework, PGSs for various psychiatric disorders may help tailor antidepressants to each patient to avoid serious adverse effects such as suicidal thoughts.

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