Phase-Amplitude Coupling, Mental Health and Cognition: Implications for Adolescence

Identifying biomarkers of developing mental disorder is crucial to improving early identification and treatment-a key strategy for reducing the burden of mental disorders. Cross-frequency coupling between two different frequencies of neural oscillations is one such promising measure, believed to reflect synchronization between local and global networks in the brain. Specifically, in adults phase-amplitude coupling (PAC) has been shown to be involved in a range of cognitive processes, including…

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