Methylphenidate and manic relapse in bipolar disorders: A replication study in a nationwide claims database

CONCLUSIONS/INTERPRETATION: In patients with treated BD, methylphenidate is only associated with manic relapse at high dose. The strong significant risk of manic relapse we observed in untreated BD may be explained by natural progression of mania. This study highlights intrinsic limitations associated with self-controlled survival analysis.

via https://pubmed.ncbi.nlm.nih.gov/42132544/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1HYeX0emtvYgH07Wkz0a8n9otrdMd-JIklc_uo0I5vh1u9WMEy&fc=None&ff=20260515010805&v=2.20.0