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Individual Variability in Reaction Time and Prediction of Clinical Response to Methylphenidate in Adult ADHD: A Prospective Open Label Study Using Conners’ Continuous Performance Test II.
J Atten Disord. 2019 Feb 14;:1087054719829822
Authors: Fredriksen M, Egeland J, Haavik J, Fasmer OB
Abstract
OBJECTIVE: The aim of this study was to examine whether reaction time parameters in adult patients with ADHD could predict their response to methylphenidate (MPH).
METHOD: Previously unmedicated patients ( N = 123) were administered the Conners’ Continuous Performance Test II (CPT II) at baseline and after 6 weeks of treatment with immediate-release MPH. In addition to traditional CPT measures, we extracted intraindividual raw data and analyzed time series using linear and nonlinear mathematical models.
RESULTS: Clinical responders, assessed with the Clinical Global Impression-Improvement scale, showed significant normalization of target failures, reduced variability and skewness, and increased complexity of reaction time series after 6 weeks of treatment, while nonresponders showed no significant changes. Prior to treatment, responders had significantly higher variability and skewness, combined with lower complexity, compared with nonresponders.
CONCLUSION: These results show that the CPT test is useful in the evaluation of treatment response to MPH.
PMID: 30762452 [PubMed – as supplied by publisher]
via https://www.ncbi.nlm.nih.gov/pubmed/30762452?dopt=Abstract