Adults with attention-deficit/hyperactivity disorder (ADHD) frequently experience residual symptoms such as cognitive fatigue, brain fog, and reduced motivation despite optimized stimulant therapy. Emerging evidence points to disrupted dopamine-glutamate coupling and insufficient synaptic pruning as contributors to these persistent deficits, suggesting a potential role for glutamatergic modulation inspired by ketamine’s rapid neuroplastic effects. This report describes a 25-year-old man with…
