Effects of NR3C1 and COMT Genes on Attention-Deficit/Hyperactivity Disorder and Accompanying Aggressiveness: A Cross-Sectional Study in a Clinical Sample

CONCLUSION: These findings suggest that COMT-related genetic variation may be associated with aggression-related features in youth with ADHD, whereas no such association was observed for both COMT and NR3C1 in this sample with advanced statistical analysis. Further studies with larger samples and more refined phenotyping are warranted to clarify the genetic architecture underlying aggression in ADHD.

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