Effect of methylphenidate exposure on glutamate and glutamate-related metabolites in patients with ADHD: a systematic review

CONCLUSION: A trend for decreased glutamate levels after MPH exposure were observed in studies involving children with ADHD. Future studies investigating the effects of MPH in children and adults with ADHD should utilise higher magnet field strength with larger sample sizes and over a longer duration of time with blinding and control group research design.

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