Recent evidence suggests the brain’s major excitatory neurotransmitter, glutamate, plays a key role in attention-deficit/hyperactivity disorder (ADHD). Here we ask if glutamate also plays a role in the variable clinical courses of ADHD. While some children ‘grow out’ of ADHD by adolescence, others experience persistent symptoms into adulthood. Prior work implicates structural and functional differences in medial prefrontal cortex as pivotal in these different ADHD symptom courses, and we now ask…
