Deletion of N-ethylmaleimide-sensitive factor in dopamine D2 receptor-expressing cells impairs striatal development and dopaminergic function and induces ADHD-like behaviors in mice

N-ethylmaleimide-sensitive factor (NSF) regulates membrane fusion, supporting neurotransmitter release and membrane protein trafficking. NSF dysfunction has been linked to neuropsychiatric disorders. Although NSF interacts with dopamine D2 receptor (D2R), and NSF reduction induces excitotoxicity in vitro, its role in D2R-expressing cells in vivo remains unclear. This study examined the effects of NSF loss on D2R-expressing cell populations and mouse behaviors. We generated D2R-specific NSF…

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