Gene-environment correlations (rGE) may drive the clinical heterogeneity of major depressive disorder (MDD) through their effects on brain structure. However, previous literature focused on isolated components of these interplays. Here, we jointly investigate how rGE shape neurobiological profiles in MDD, and whether rGE-driven brain signatures can disentangle depression subtypes. In 5951 MDD patients with genetic, trauma-related and neuroimaging data from the UK Biobank, cross-validated sparse…
