Atypical depression is associated with a distinct clinical, neurobiological, treatment response and polygenic risk profile

CONCLUSIONS: This large genetically-informative study supports the neurobiological and clinical validity of atypical depression, demonstrating distinct clinical and genetic risk profiles alongside differential antidepressant responses. These support utilizing the atypical subtype to guide treatment selection and physical health management.

via https://pubmed.ncbi.nlm.nih.gov/41534638/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1lqZ3NPYysePVKsoyz66mDSgu4veDGJwnUBS47TBQPoOuNZY5J&fc=None&ff=20260127011007&v=2.18.0.post22+67771e2