Methylphenidate is known to alleviate attention-deficit/hyperactivity disorder (ADHD) symptoms. However, methylphenidate’s age-dependent effects on brain structure have not been well studied. This longitudinal MRI study investigated the effect of cumulative methylphenidate exposure on brain structure and ADHD-related symptoms. Eighty-nine individuals with DSM-5 ADHD and 91 typically developing controls (TDC) were assessed with MRI for brain structure and the parent-rated SNAP-IV questionnaire…
