Altered pain processing and associated neural circuitry disruptions in adolescents with early-onset psychosis

CONCLUSIONS: This study shows a preliminarily association between disruptions in cortico-striatal-thalamic circuitry, pain processing, and somatosensory disturbances in EOP. Upon further longitudinal validation in a larger cohort, markers of altered pain processing may provide a clinically accessible index of neurobiological disturbances underlying psychopathology in EOP.

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