Identifying shared and personalized brain functional connectivity subspace across neuropsychiatric disorders

Objective.Neuropsychiatric disorders exhibit complex functional connectivity (FC) alterations, yet disentangling transdiagnostic mechanisms from disorder-specific network perturbations remains challenging due to clinical heterogeneity and multisite data confounds.Approach.We aggregated large-scale resting-state fMRI data from 1923 patients with major depressive disorder (MDD), autism spectrum disorder (ASD), or attention-deficit/hyperactivity disorder (ADHD), and site-matched controls from the…

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