Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome with an inherited (Mendelian) form (primary HLH, pHLH), of which familial HLH (FHL) is most prevalent, and an acquired (non-Mendelian) form (secondary HLH, sHLH); both potentially rapidly fatal. As more patients survive, evaluating long-term morbidity, especially neurological complications, is important. Here we report on CNS involvement at onset, its impact on mortality and morbidity, and long-term follow-up in 365…
