Pharmacotherapy persistence in adults with attention-deficit/hyperactivity disorder (ADHD) remains concerning; however, evidence describing early treatment changes and discontinuation is limited. This study aimed to describe initial ADHD pharmacotherapy patterns and quantify claims-based initial regimen instability in Japanese adults. Using a Japanese claims database, we assembled a cohort of adults who initiated ADHD medication with methylphenidate, atomoxetine, guanfacine, or polytherapy…
