Although Atopic Dermatitis (AD) and Attention-Deficit/Hyperactivity Disorder (ADHD) frequently coexist in children, the underlying mechanisms remain unclear. The “Skin-Brain Axis”(SBA) hypothesis, based on the shared ectodermal origin of the skin and the central nervous system(CNS), provides a theoretical foundation for communication between AD and ADHD. However, standardized biomarkers and direct clinical validation are currently lacking. Interleukin-4 (IL-4), a key cytokine driving skin…
