Shared genetic architecture between psychiatric and insulin-related traits in the general population

Psychiatric conditions, like Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Obsessive-Compulsive Disorder (OCD) are complex heritable disorders that frequently co-occur with insulin resistance (IR)-related conditions, such as obesity and type 2 diabetes mellitus. Traditional genetic case-control comparisons are challenged by the extent of heterogeneity and comorbidity within and across these conditions. In this study we used psychiatry-related traits in the…

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