Neuroinflammation is a potential pathogenesis of attention deficit hyperactivity disorder (ADHD). However, its consistency and specific causality remain unclear. We investigated the causal relationship between 91 inflammatory proteins and ADHD and explored the potential mediating role of 1400 serum metabolites. We obtained genome-wide association study (GWAS) data for 91 inflammatory proteins (n = 14,824), 1400 metabolites (n = 8299) and ADHD (n = 38,691) from publicly available datasets. A…
