Adolescence is a sensitive period for the maturation of prefrontal GABAergic circuitry, particularly involving parvalbumin-expressing (PV+) interneurons that regulate excitatory-inhibitory balance and support attentional control. Methylphenidate (MPH), widely prescribed for attention-deficit/hyperactivity disorder (ADHD, is commonly administered throughout adolescence, yet its long-term impact on PV+ interneuron development remains unclear. Here, we examined whether chronic MPH exposure during…
