CONCLUSIONS: TS in children predominantly affects males and is commonly associated with ADHD and OCD. Coprolalia-a clinically distressing symptom-was present only in a small subgroup. The lower plasma vitamin B6 levels observed in children with TS suggest a possible role for vitamin B6 in disease pathogenesis, potentially through its involvement in histaminergic and GABAergic neurotransmission and in modulating neuroinflammatory processes.
