Cortical morphometric inverse divergence in attention-deficit/hyperactivity disorder correlates with cell-type-specific, laminar-specific and developmental transcriptomic signatures

CONCLUSIONS: This study links macroscale cortical abnormalities to microscale transcriptional regulation, with pronounced alterations in ADHD-C. The shared genetic and functional profiles between ADHD and its combined subtype underscore common pathological processes, providing novel insights into the neurodevelopmental mechanisms of ADHD.

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