Dexamfetamine (DEX) and lisdexamfetamine (LDX) are both prescribed to treat adult ADHD in the Netherlands. LDX is marketed as a long-acting prodrug of DEX requiring once-daily dosing, unlike DEX, which typically is administered two times daily. However, empirical evidence for this distinct dosing regimens remains sparse. This open-label, cross-over study compared the daytime effects of bioequivalent doses of DEX (twice daily) and LDX (once daily) in sixteen adults with ADHD. It was hypothesized…
