In vitro exposure to atomoxetine hydrochloride reduces testosterone biosynthesis, induces cell death and DNA damage, as well as altering the oxidative profile and gene expression in TM3 Leydig cells

Atomoxetine, a drug used in the treatment of Attention Deficit/Hyperactivity Disorder, acts by increasing the availability of neurotransmitters, which can act on the male genital system. The effects of this substance on Leydig cells, which are responsible for testosterone production, have not been described. This study aimed to investigate the in vitro effects of atomoxetine hydrochloride (250, 1000 or 1750 ng/mL) on DNA damage (4 h), gene expression (12h), and after 24 h, cell viability and…

via https://pubmed.ncbi.nlm.nih.gov/41967611/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1L37KAMf2b_g4WEK3LmdFuKZu9pO3cN7u4ZmO9PPCPeBLMIw1q&fc=None&ff=20260424010911&v=2.19.0.post6+133c1fe


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