Adult ADHD with comorbid major depression shows a distinguishable polygenic pattern and negative cognitive style

Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder, and comorbidity with other mental diseases is common. Specifically, adult ADHD (aADHD) is highly comorbid with major depressive disorder (MDD). A genetic correlation between ADHD and MDD might underlie the risk of comorbidity of both disorders. However, whether patients with ADHD and comorbid MDD differ genetically from those without comorbid MDD is currently unclear. We therefore studied the…

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