The genetic risk of mental health disorders in children from diverse population-based cohorts is modulated by poverty

Attention-deficit/hyperactivity disorder (ADHD) and depression share substantial genetic liability, yet the extent to which socioeconomic disadvantage shapes the expression of this genetic risk remains unclear. We investigated whether poverty moderates and mediates associations between polygenic risk scores (PGS) for ADHD and major depressive disorder (MDD) and corresponding symptoms in early adolescence. Data were drawn from two population-based cohorts: the 2004 Pelotas Birth Cohort (Brazil; N…

via https://pubmed.ncbi.nlm.nih.gov/41727570/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1lqZ3NPYysePVKsoyz66mDSgu4veDGJwnUBS47TBQPoOuNZY5J&fc=None&ff=20260304011006&v=2.19.0.post6+133c1fe


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