CLINICAL CHARACTERISTICS: Clinical features of int22h1/int22h2-mediated Xq28 duplication syndrome in males can include mild-to-moderate developmental delay / intellectual disability, a characteristic behavioral profile (aggression, irritability, ADHD, autism, anxiety, sleep disturbance, and socialization issues), recurrent sinopulmonary infections (e.g., otitis media, sinusitis, recurrent upper respiratory tract infections), atopic conditions (i.e., asthma, allergic rhinitis, and eczema),…
