Monosodium glutamate (MSG), an umami substance, activates the gut-brain axis via vagus nerves. However, the brain mechanism involved in the effect of MSG on aggression during the developmental period has not been clarified. SHR/Izm, a known model of attention-deficit hyperactivity disorder (ADHD), was used to investigate the effect of MSG oral ingestion (60 mM solution) on aggression. The resident-intruder test was performed in rats, with a detailed analysis of aggressive behavior, including the…
