CONCLUSIONS: Across 21 primary studies, RTL definitions varied greatly, and similarly, a wide range of days to RTL was seen at 3-35 days. Female gender and initial symptom severity were most consistently associated with prolonged RTL. Certain factors such as a history of ADHD/anxiety showed potential effects but require further investigation. Management guidelines should consider these findings while recognizing the need for more comprehensive research to confirm and quantify the impact of…
