Prolonged Amphetamine-Dextroamphetamine Use: An Unrecognized Cause of Cardiomyopathy

Adderall (amphetamine-dextroamphetamine), manufactured by Shire, Teva, and Impax Pharmaceuticals (Lexington, MA), is a commonly prescribed stimulant for attention-deficit/hyperactivity disorder (ADHD). It contains a combination of mixed amphetamine salts that enhance the activity of dopamine and norepinephrine in the brain. While generally well-tolerated, prolonged use has been associated with adverse cardiovascular effects, including cardiomyopathy. This condition, characterized by structural…

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