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Methylphenidate Alters Functional Connectivity of Default Mode Network in Drug-Naive Male Adults With ADHD.
J Atten Disord. 2018 Dec 10;:1087054718816822
Authors: Picon FA, Sato JR, Anés M, Vedolin LM, Mazzola AA, Valentini BB, Cupertino RB, Karam RG, Victor MM, Breda V, Silva K, da Silva N, Bau CHD, Grevet EH, Rohde LAP
Abstract
OBJECTIVE: This study evaluated the hypothesis that methylphenidate immediate release (MPH-IR) treatment would improve Default Mode Network (DMN) within-connectivity.
METHOD: Resting-state functional connectivity of the main nodes of DMN was evaluated in a highly homogeneous sample of 18 drug-naive male adult participants with ADHD.
RESULTS: Comparing resting-state functional connectivity functional magnetic resonance imaging (R-fMRI) scans before and after MPH treatment focusing exclusively on within-DMN connectivity, we evidenced the strengthening of functional connectivity between two nodes of the DMN: posterior cingulate cortex (PCC) and left lateral parietal cortex (LLP).
CONCLUSION: Our results contribute to the further understanding on how MPH affects functional connectivity within DMN of male adults with ADHD and corroborate the hypothesis of ADHD being a delayed neurodevelopmental disorder.
PMID: 30526190 [PubMed – as supplied by publisher]
via https://www.ncbi.nlm.nih.gov/pubmed/30526190?dopt=Abstract