Metabolomics research offers promising potential for identifying key metabolites and exploring the pathophysiological underpinnings of attention-deficit hyperactivity disorder (ADHD). However, serum metabolomics in ADHD remains largely uncharted. Our study aimed to search for metabolomic biomarkers in children with ADHD. 70 drug-naïve children diagnosed with ADHD according to DSM-5 criteria and 70 sex-, age-, IQ-matched healthy controls were recruited from the National Taiwan University…