Chronic modulation of endocannabinoid receptors does not impact hyperactivity, risk behavior, and working memory in an animal model of attention-deficit/hyperactivity disorder

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by impairments in executive functions, including behavioral inhibition and working memory. The most widely accepted neurobiological explanation for ADHD is related to dopaminergic hypofunction. The dopaminergic system is modulated by endocannabinoid ligands, primarily through the action of cannabinoid receptors type 1 and 2 (CB1R and CB2R) within frontostriatal circuits. Spontaneously hypertensive rats…

via https://pubmed.ncbi.nlm.nih.gov/40617332/?utm_source=Other&utm_medium=rss&utm_campaign=None&utm_content=1lqZ3NPYysePVKsoyz66mDSgu4veDGJwnUBS47TBQPoOuNZY5J&fc=None&ff=20250717011008&v=2.18.0.post9+e462414