The Time Course of Effect of Multilayer-Release Methylphenidate Hydrochloride Capsules: A Randomized, Double-Blind Study of Adults With ADHD in a Simulated Adult Workplace Environment.
J Atten Disord. 2016 Oct 17;:
Authors: Wigal SB, Wigal T, Childress A, Donnelly GA, Reiz JL
Abstract
OBJECTIVE: The aim of this study is to assess the onset and duration of efficacy of multilayer-release methylphenidate (PRC-063) over 16 hr compared with placebo in adults with ADHD using the simulated adult workplace environment.
METHOD: After dose-optimization with PRC-063, participants entered a double-blind, placebo-controlled, crossover phase. Primary outcome measure was the Permanent Product Measure of Performance (PERMP) total score measured pre-dose and from 1 to 16 hr post-dose.
RESULTS: Of the 59 randomized participants, 45 participants completed the study. While receiving PRC-063, adults had greater improvement from pre-dose in mean PERMP total scores across all time points compared with placebo (51.5 ± 29.22 vs. 23.9 ± 31.27; p < .0001). Common adverse events were decreased appetite, headache, and insomnia. There was no significant impact on overall sleep quality (p = .9542).
CONCLUSION: PRC-063 significantly improved PERMP scores with an onset within 1 hr post-dose, and maintained improvement throughout the 16 hr post-dose study period compared with placebo in adults with ADHD.
PMID: 27756854 [PubMed – as supplied by publisher]
via https://www.ncbi.nlm.nih.gov/pubmed/27756854?dopt=Abstract