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A neuromarker of sustained attention from whole-brain functional connectivity.
Nat Neurosci. 2016 Jan;19(1):165-71
Authors: Rosenberg MD, Finn ES, Scheinost D, Papademetris X, Shen X, Constable RT, Chun MM
Abstract
Although attention plays a ubiquitous role in perception and cognition, researchers lack a simple way to measure a person’s overall attentional abilities. Because behavioral measures are diverse and difficult to standardize, we pursued a neuromarker of an important aspect of attention, sustained attention, using functional magnetic resonance imaging. To this end, we identified functional brain networks whose strength during a sustained attention task predicted individual differences in performance. Models based on these networks generalized to previously unseen individuals, even predicting performance from resting-state connectivity alone. Furthermore, these same models predicted a clinical measure of attention–symptoms of attention deficit hyperactivity disorder–from resting-state connectivity in an independent sample of children and adolescents. These results demonstrate that whole-brain functional network strength provides a broadly applicable neuromarker of sustained attention.
PMID: 26595653 [PubMed – indexed for MEDLINE]
via http://www.ncbi.nlm.nih.gov/pubmed/26595653?dopt=Abstract